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Case Studies and Reviews

First Preclinical Study

Dr. Ko's first preclinical study was more successful than anyone could have imagined. This mouse model seeded 34 mice with hepatocellular carcinoma with 19 mice treated with 3BP and 15 untreated mice serving as controls. All 19 treated mice were completely cured and lived out a normal lifespan, while all 15 controls had to be euthanized. 
Second Preclinical Study

Though the second preclinical study does not appear to be as dramatic or spectacular as the first, that understanding is far from true. In many ways, Dr. Ko feels that the significance of the second study was critical for her to validate the safety and potential toxicology of KAT ultimately for human use. 

Third Preclinical Study

This preclinical study was in partnership with the University of Maryland in 2018 and tested KAT’s effectiveness in conjunction with Radiation Therapy (RT). These results have been particularly exciting, as it was designed to explore the effect of 3BP on tumor growth in non-small cell lung cancer. 

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First Human to Receive 3BP
This photograph of the first recipient of 3BP for cancer, Yvar Verhoeven, in this Case Report was poised with the novel anticancer agent, 3-bromopyruvate (3BP) and his favorite legendary immortal bird, phoenix. The picture was taken on his 18th birthday, September 09, 2009, at his home in the Netherlands, after his 7th treatment with 3BP. This was a very special day as he had been told that he would never make it to his 17th birthday. 
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